Excel · study · 2026
Bulk RNA-seq of young HSCs and Selp high vs Selp low HSCs in pre-aged mice
Listed in NCBI GEO
Hematopoietic stem cells (HSCs) undergo functional and molecular alterations during aging that impair regenerative capacity and bias lineage output.
Description
P-selectin (Selp/CD62P) expression has been associated with inflammatory and stress-responsive hematopoietic states, but its transcriptional impact within the HSC compartment during early aging remains incompletely defined. In this study, we performed bulk RNA sequencing of phenotypically defined HSCs isolated from young mice and from pre-aged mice in which HSCs were further stratified based on Selp surface expression (Selp_high and Selp_low).
Comparative transcriptomic analysis was conducted to identify gene expression programs associated with early aging and Selp-associated heterogeneity within the HSC pool. These data provide a resource for understanding molecular pathways linked to HSC functional decline and inflammatory priming during the initial stages of hematopoietic aging.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319049 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319049 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1389814 ncbi.nlm.nih.gov/bioproject/PRJNA1389814 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE319049 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |