Omics · study · 2026
Transcriptome analysis of early human placenta and idiopathic recurrent pregnancy loss samples
Listed in NCBI GEO
The goal of this study was to test gene expression changes in developing human placenta, which are associated with idiopathic recurrent pregnancy losses (RPL).
Description
In particular, we focused on RPL placental tissues that show significant defect in villi organization. Placental samples (less that 15 weeks) were collected. 4 control placentae with normal villi structure and 4 RPL placentae with defective villi formation were collected and ensured tissue viability.
Whole placental villi were used to prepare RNA using Qiagen RNeasy Mini Kit with on column DNase digestion. RNA-seq analysis were performed using a NovaSeq 6000 platform.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE306nnn/GSE306548 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE306548 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1311103 ncbi.nlm.nih.gov/bioproject/PRJNA1311103 ↗
project · from NCBI GEO
- PubMed 42431891 pubmed.ncbi.nlm.nih.gov/42431891 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE306548 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |