Data · dataset · 2026
Respostas de neutrófilos humanos à disbiose intestinal induzida por antibióticos: um conjunto de dados longitudinal multiômico com caracterização imunológica e clínica
Listed in REDU - Unicamp Institutional Research Data Repository
Este conjunto de dados reúne dados longitudinais multiômicos e de perfis imunológicos/clínicos, gerados como parte de um projeto de doutorado na Unicamp, que investiga como a disbiose intestinal induzida por antibióticos modula neutrófilos humanos.
Description
Inclui amostras pareadas pré- e pós-antibiótico de adultos saudáveis submetidos a um regime de amplo espectro por três dias (coletas realizadas em 2021-2022), possibilitando análises pareadas de medidas do hospedeiro e do microbioma.
As medidas incluem transcriptômica de neutrófilos (RNA-seq), epigenômica de neutrófilos (ATAC-seq) e análise do perfil da microbiota fecal (sequenciamento de amplicons do 16S rRNA), além de quantificação de citocinas, citometria de fluxo, RT-qPCR, entre outros. Os dados não podem ser disponibilizados por questões de proteção intelectual. Para mais informações, favor contatar os responsáveis pelo depósito.
Read the rest (2 more)
This dataset comprises longitudinal multi-omics and immune/clinical profiling data generated as part of a doctoral project at UNICAMP investigating how antibiotic-induced gut dysbiosis modulates human neutrophils. It includes matched pre- and post-antibiotic samples from healthy adults following a three-day broad-spectrum regimen (collected in 2021-2022), enabling paired analyses of host and microbiome readouts. Readouts include neutrophil transcriptomics (RNA-seq), neutrophil epigenomics (ATAC-seq), and fecal microbiome profiling (16S rRNA amplicon sequencing), as well as cytokine quantification, flow cytometry, RT-qPCR, and related measures.
The data cannot be made available due to intellectual property protection. For further information, please contact the repository administrators.
Links
Where it is published
- Dataverse dataset page redu.unicamp.br/dataset.xhtml?persistentId=doi%3A10.25824%2Fredu%2F6XFA33 ↗
landing page · from redu unicamp br
- DOI doi.org/10.25824/redu/6xfa33 ↗
DOI / persistent id · from redu unicamp br
Catalogue records · 1
- Dataverse API redu.unicamp.br/api/datasets/:persistentId/?persistentId=doi%3A10.25824%2Fredu… ↗
metadata API · from redu unicamp br
Topics
- Stated by source
- Medicine, Health and Life Sciences
- From keywords
- Innate immunity · Life Sciences · Medicine & Health
- Inferred from text
- Longitudinal study 65% · RNA sequencing 65% · Sequencing 75%
Provenance · 1 source records, 13 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| REDU - Unicamp Institutional Research Data Repository | doi:10.25824/redu/6XFA33 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| concepts[field].anzsrc:field:320407 | mapping · redu unicamp br | vocabulary-mapper@1.0.0 | keywords['Innate immunity'] |
| concepts[field].dataverse_subject:medicine-health-and-life-sciences | source · redu unicamp br | connector:redu_unicamp_br@1.0.0 | /subjects |
| concepts[field].local:field:life-sciences | mapping · redu unicamp br | connector:redu_unicamp_br@1.0.0 | /subjects |
| concepts[field].local:field:medicine-health | mapping · redu unicamp br | connector:redu_unicamp_br@1.0.0 | /subjects |
| concepts[method].local:method:longitudinal-study | enrichment · redu unicamp br | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:rna-seq | enrichment · redu unicamp br | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:sequencing | enrichment · redu unicamp br | keyword-concept-rules@1.0.0 | title+description (75%) |
| created_date | source · redu unicamp br | connector:redu_unicamp_br@1.0.0 | |
| description | source · redu unicamp br | connector:redu_unicamp_br@1.0.0 | /description |
| publication_date | source · redu unicamp br | connector:redu_unicamp_br@1.0.0 | |
| title | source · redu unicamp br | connector:redu_unicamp_br@1.0.0 | /name |
| updated_date | source · redu unicamp br | connector:redu_unicamp_br@1.0.0 | |
| version_label | source · redu unicamp br | connector:redu_unicamp_br@1.0.0 |