Data · study · 2026
Transcriptom modulated by LDOC1 / H2Bub1 axis
Listed in NCBI GEO
Monoubiquitination of histone H2B on lysine 120 (H2Bub1) is one of the prominent epigenetic marks that regulates multiple cellular processes, including immunity, stem cell differentiation, tumorigenesis, and DNA damage response, mainly through affecting transcription of specific gene sets.
Description
The Ring Finger Protein 40 (RNF40) and its paralog RNF20 forms a stable E3 ligase heterodimer is the major enzymatic complex responsible for H2B monoubiquitylation.
Dysregulation of H2Bub1 was observed in early stage of non-small cell lung carcinoma (NSCLC). However, the underlying regulatory mechanism and the impact of aberrant H2Bub1 level in the metastasis and chemotherapy response of NSCLC patients remains unelucidated. We found LDOC1 associated with RNF40 in NSCLC A549 cells.
Read the rest (1 more)
In this study, we investigate the role of LDOC1 in epigenome and aggressiveness of NSCLC involving H2Bub1.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE246nnn/GSE246303 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE246303 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1032453 ncbi.nlm.nih.gov/bioproject/PRJNA1032453 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by array · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE246303 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |