Omics · study · 2026
Disease-associated microglia adopt stage-specific phenotypes that regulate T cell fate and immunity in glioma
Listed in NCBI GEO
Glioma microenvironment contains numerous myeloid cells, including brain-resident microglia and recruited monocytes and macrophages (Mo/Mφ).
Description
Previous researches studied these cells collectively and revealed their pro-tumor effects. Yet, little is known about the differences among these myeloid populations.
Here we revealed the phenotypic characteristics, spatial variances, and dynamic changes of these relatively heterogeneous cell populations by single-cell sequencing analysis. Microglia were pro-inflammatory transiently, and soon skewed to restore the homeostasis of the central nervous system (CNS). Notably, a subset of glioma-associated microglia shared similar trait in a diverse spectrum of neuropathogenesis.
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Mo/Mφ, on the other hand, were responsible for various tumor-promoting effects, such as angiogenesis, tumor invasion, and immune evasion. Moreover, the Mo/Mφ subsets presented prognostic and classificatory value in clinical application. Conclusively, these results eliminate the long-existing ambiguity about the role of microglia and Mo/Mφ in glioma pathogenesis, and reveal their prognostic and therapeutic value for glioma patients.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE171nnn/GSE171081 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE171081 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA718289 ncbi.nlm.nih.gov/bioproject/PRJNA718289 ↗
project · from NCBI GEO
- PubMed 42497861 pubmed.ncbi.nlm.nih.gov/42497861 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE171081 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |