Omics · study · 2026
Combination of MEK and Autophagy Inhibition in the preclinical GEMM model of PDAC (KPC mice)
Listed in NCBI GEO
In order to investigate the mechiansim of action and the effect of the combination of MEK/Autophagy Inhibition on pancreatic tumors, KPC mice were treated with Vehicle or combination of Trametinib and Hydroxychloroquine for 24 hours.
Description
PDAC tumors were collected and single cell suspension was subjected to single-cell RNA-Sequencing analysis.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE274nnn/GSE274516 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE274516 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1146933 ncbi.nlm.nih.gov/bioproject/PRJNA1146933 ↗
project · from NCBI GEO
- PubMed 42284543 pubmed.ncbi.nlm.nih.gov/42284543 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE274516 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |