Omics · study · 2026
Transcriptomic profiling of Visceral Adipose Tissue (VAT) in a neonatal STZ-induced diabetes model: modulatory effects of Curcumin. [RNA-Seq]
Listed in NCBI GEO
Visceral Adipose Tissue (VAT) plays a pivotal role in the systemic metabolic complications of Type 2 Diabetes, acting as a primary site for pro-inflammatory cytokine secretion and lipid storage failure.
Description
In this study, we utilized a combined neonatal Streptozotocin (nSTZ) and High-Fat Diet (HFD) model to simulate the progression of diabetic adipopathy in C57BL/6 mice. The objective was to characterize the transcriptomic response of VAT to chronic hyperglycemia and lipid overload, and to evaluate the potential of Curcumin (50 mg/kg) as a metabolic and inflammatory modulator.
Following 28 days of daily treatment via oral gavage, VAT samples were collected for total RNA sequencing. These data contribute to the understanding of the molecular mechanisms underlying adipose tissue dysfunction in diabetes and highlight the role of Curcumin in modulating the transcriptomic profile landscape to improve metabolic health.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE329nnn/GSE329567 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE329567 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1459688 ncbi.nlm.nih.gov/bioproject/PRJNA1459688 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE329567 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |