Omics · study · 2026
Dermal Lyve1+FolR2+ perivascular macrophages act as sentinels against intravascular infections
Listed in NCBI GEO
Initiation of innate immune responses often relies on pathogen sensing by tissue-resident myeloid cells, typically macrophages and dendritic cells.
Description
However, how the innate immune system senses and mounts an efficient response to intravascular infections remains unclear. Here, we addressed this question in the context of Neisseria meningitidis intravascular infection.
We found that dermal macrophages can respond to these bacteria by secreting chemokines that allow neutrophil recruitment to the lumen of infected vessels. Single cell sequencing, flow cytometry analysis, and intravital imaging revealed that this process relies on a population of Lyve1+ FolR2+ perivascular macrophages that continuously samples the blood and elicits a pro-inflammatory response in response to N. meningitidis uptake.
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These results shed light on the key role played by perivascular macrophages in the immune surveillance of the vascular compartment and further provide a causal sequence of events leading to the initiation of innate immune responses against intravascular infections.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE306nnn/GSE306016 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE306016 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1308948 ncbi.nlm.nih.gov/bioproject/PRJNA1308948 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Imaging 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE306016 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:imaging | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |