Excel · study · 2026
Elevation of caldesmon-1 is essential for the differentiation of aortic valve interstitial cells into osteoblasts.
Listed in NCBI GEO
The molecular mechanisms underlying calcification and fibrosis in aortic valve leaflets remain unclear.
Description
This study highlights the functional roles of Caldesmon1 (CALD1), a cytoskeletal regulatory protein, in the progression of calcific aortic valve disease (CAVD), with a focus on its effect on valvular interstitial cell (VIC) behavior and osteoblast differentiation. RNA-seq analysis combined with ingenuity pathway analysis was performed to clarify the functional roles of CALD1 in aortic valve calcification.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE284nnn/GSE284183 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE284183 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1197517 ncbi.nlm.nih.gov/bioproject/PRJNA1197517 ↗
project · from NCBI GEO
- PubMed 41703153 pubmed.ncbi.nlm.nih.gov/41703153 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE284183 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |