Data · dataset · 2026
Investigating the role of BTKi and the histone variant macroH2A1 in chronic lymphocytic leukaemia
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32639439.v1
Chronic Lymphocytic Leukaemia (CLL) is a highly heterogeneous CD5+ lymphoproliferative disorder.
Description
Epigenetic phenomena play an important role in CLL. Bruton’s tyrosine kinase (BTK), part of the B cell receptor signalling, has been targeted therapeutically and has led to a paradigm shift in CLL treatment.
BTK inhibition by Ibrutinib has been associated with changes at the epigenetic level and shown to alter the CLL enhancer landscape.<br><br>A MACROH2A1-related Ibrutinib-responsive active region was discovered in matched pre-/post-Ibrutinib treated CLL samples by H3K27ac ChIP-seq. MacroH2A1 is a histone variant with an important role in genome stability. Additionally, integrated analysis of this ChIP-seq with RNA-seq data from the matched pre-/post-Ibrutinib treated CLL patient samples revealed several genes shown to be altered upon Ibrutinib.
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Together, patient and cell lines data suggest Ibrutinib may have an impact on macroH2A1 and its isoforms in CLL as well as other genes.<br><br>This work provides first evidence for a role of macroH2A1 and its epigenetic regulation in CLL in the context of BTK inhibitor treatment. The multifaceted role of macroH2A1 in disease, its potential as a therapeutic target and the knowledge gap in the CLL/BTK context, suggest that dissection of macroH2A1’s role on the epigenetic axis demands further investigation.<br><br><i>Thesis is embargoed until 31 July 2029</i>.<br><br><br>
Links
Where it is published
- DOI doi.org/10.17034/32639439.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Cancer · Cancer · Cancer · Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Epigenetics · Epigenetics · Epigenetics · Medicine & Health · Medicine & Health · Medicine & Health
- Inferred from text
- Disease 75% · RNA sequencing 65%
Provenance · 3 source records, 19 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32639439 | 13 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32639439 | 13 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32639439 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[disease].local:disease:cancer | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['cancer'] |
| concepts[disease].local:disease:cancer | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['cancer'] |
| concepts[disease].local:disease:cancer | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['cancer'] |
| concepts[disease].local:disease:disease | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:field:310504 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['epigenetics'] |
| concepts[field].anzsrc:field:310504 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['epigenetics'] |
| concepts[field].anzsrc:field:310504 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['epigenetics'] |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[modality].local:modality:rna-seq | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (65%) |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |