Omics · study · 2026
RNA-seq and ATAC-seq of Psc Su(Z)2 -/- intestinal stem cells in Drosophila
Listed in NCBI GEO
Polycomb group (PcG) genes function as epigenetic silencers that maintain the repressive states of target genes essential for normal development.
Description
To elucidate the role of PRC1 components in the Drosophila midgut, we performed both RNA-seq and ATAC-seq analyses on intestinal stem cells (ISCs) deficient for PRC1 and Su(z)2. For RNA-seq controls, besides the esgts>GFP, we included ISCs harboring mutations in the Notch signaling pathway (N55e11) and the JAK-STAT pathway (dome468) as additional controls.
What's more, ATAC-seq was also performed on pc-RNAi and E(z)-RNAi ISCs which represent other components of PRC1 and PRC2, respectively.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE299nnn/GSE299390 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE299390 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1274248 ncbi.nlm.nih.gov/bioproject/PRJNA1274248 ↗
project · from NCBI GEO
- PubMed 42323466 pubmed.ncbi.nlm.nih.gov/42323466 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Drosophila melanogaster · Expression profiling by high throughput sequencing · Genome binding/occupancy profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE299390 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:7227 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |