Omics · study · 2026
Effect of TTYH2 Knockout on Gene Expression During DMXAA Treatment in Mouse Peritoneal Macrophages [RNA-seq]
Listed in NCBI GEO
Beyond regulators of myeloid cell activity, the myeloid-derived cytokine network controlled by type I interferons (IFN-α/β, IFN) is of particular importance, serving as a central determinant bridging both innate and adaptive immunity.
Description
Here we report that TTYH2 potently restrains NF-κB/IRF signaling and the production of type I interferons. RNA-seq of DMXAA-stimulated Ttyh2 wildtype and knockout mice peritoneal macrophages revealed striking upregulation of type I IFN-stimulated genes, NF-κB regulators, cytokines/chemokines, antigen-presentation genes, costimulatory molecules, and adhesion/integrin signaling.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE307nnn/GSE307668 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307668 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1322489 ncbi.nlm.nih.gov/bioproject/PRJNA1322489 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE307668 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |