Omics · study · 2026
Spp1 Mediates Antimony Trioxide-Induced Male Reproductive Toxicity via Regulating Inflammatory Response and Blood-Testis Barrier Integrity
Listed in NCBI GEO
This study investigated the male reproductive toxicity of antimony trioxide (Sb₂O₃) using in vivo male mice and in vitro TM4 Sertoli cell models.
Description
Sb₂O₃ exposure impaired spermatogenesis, triggered inflammatory responses, and disrupted blood-testis barrier integrity by upregulating Spp1, whereas Spp1 knockdown effectively alleviated Sb₂O₃-induced inflammation, cell migration dysfunction and tight junction protein loss, identifying Spp1 as a crucial regulator of Sb₂O₃-mediated male reproductive injury.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE330nnn/GSE330989 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE330989 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1466410 ncbi.nlm.nih.gov/bioproject/PRJNA1466410 ↗
project · from NCBI GEO
- PubMed 42515134 pubmed.ncbi.nlm.nih.gov/42515134 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE330989 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |