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Omics · study · 2026

RNA-sequencing of primary mouse lung fibroblasts treated with TGF-β1

Listed in NCBI GEO

Fibroblast activation is accompanied by extensive transcriptional and metabolic remodeling that supports extracellular matrix production during pulmonary fibrosis.

Description

In this study, we investigated how palmitoleic acid, a lipid mediator generated by BAAMs through SCD1-dependent lipid remodeling, influences the transcriptional state of activated lung fibroblasts. Bulk RNA sequencing of primary mouse lung fibroblasts revealed coordinated upregulation of glycolytic pathways and suppression of oxidative phosphorylation and fatty-acid oxidation following fibroblast activation.

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Stated by source
Expression profiling by high throughput sequencing · Mus musculus
From keywords
Life Sciences
Inferred from text
RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
SourceKeyLast seenRaw
NCBI GEOGSE34285813 d agoJSON v1
FieldAssertionExtractorEvidence
access_levelsource · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[field].local:field:life-sciencesmapping · NCBI GEOconnector:ncbi_geo@1.0.0
concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencingsource · NCBI GEOconnector:ncbi_geo@1.0.0/gdstype
concepts[modality].local:modality:rna-seqenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[modality].local:modality:sequencingenrichment · NCBI GEOkeyword-concept-rules@1.0.0title+description (75%)
concepts[organism].NCBITaxon:10090source · NCBI GEOconnector:ncbi_geo@1.0.0/taxon
descriptionsource · NCBI GEOconnector:ncbi_geo@1.0.0/summary
publication_datesource · NCBI GEOconnector:ncbi_geo@1.0.0
titlesource · NCBI GEOconnector:ncbi_geo@1.0.0/title