Excel · study · 2026
Piezo1 Modulates Hematopoietic Homeostasis and Chronic Myelomonocytic Leukemia Progression
Listed in NCBI GEO
We identified that PIEZO1 is crucial for maintaining hematopoietic homeostasis and is highly expressed in patients with chronic myelomonocytic leukemia (CMML), correlating with disease progression.
Description
To elucidate the underlying mechanism, we analyzed the gene expression profiles of c-Kit⁺ cells isolated from Nrasᴳ¹²ᴰ/ᴳ¹²ᴰ; Mx1-Cre CMML mice, CMML mice with conditional Piezo1 knockout, and control mice for comparative analysis.
Our findings revealed that the cell adhesion pathway was one of the significantly enriched terms among the differentially expressed genes in Piezo1 conditional knockout (cKO) c-Kit⁺ cells, which was associated with altered expression of integrins.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313609 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313609 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1380393 ncbi.nlm.nih.gov/bioproject/PRJNA1380393 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE313609 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |