Omics · study · 2026
A Comparative Analysis of the Methylation Status of Non-Coding RNA promoters in Fibroid and Matched Myometrium
Listed in NCBI GEO
Genomic DNA from 8 paired uterine leiomyoma (fibroid) and matched myometrial tissues was analyzed using the Arraystar Human ncRNA Promoter Array (4×180K) combined with methylated DNA immunoprecipitation (MeDIP-chip).
Description
This platform interrogates promoter regions of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) to identify DNA methylation enrichment patterns. Differential promoter methylation analysis identified 538 lncRNAs and 61 miRNAs with significant differences between fibroid and matched myometrium.
Among these, 300 lncRNAs and 47 miRNAs showed increased promoter methylation, whereas 238 lncRNAs and 14 miRNAs showed decreased promoter methylation in fibroid tissues.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE324nnn/GSE324138 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE324138 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1433501 ncbi.nlm.nih.gov/bioproject/PRJNA1433501 ↗
project · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Methylation profiling by array · Non-coding RNA profiling by array
- From keywords
- Life Sciences
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE324138 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:methylation-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].geo_series_type:non-coding-rna-profiling-by-array | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |