Omics · study · 2026
RNA-Seq of T26-treated and untreated MC38 cell
Listed in NCBI GEO
This study investigates the transcriptional changes in murine colon adenocarcinoma MC38 cells in response to treatment with T26, a novel compound designed to modulate glutamine metabolism and immune-related pathways.
Description
RNA sequencing (RNA-Seq) was performed to compare the transcriptomic profiles of MC38 cells treated with T26 versus untreated controls. Differentially expressed genes were analyzed to elucidate the molecular mechanisms underlying T26-mediated anti-tumor activity.
This dataset provides a resource for understanding how T26 impacts tumor cell-intrinsic gene expression and may inform its potential role in cancer immunotherapy.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE297nnn/GSE297452 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE297452 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1263868 ncbi.nlm.nih.gov/bioproject/PRJNA1263868 ↗
project · from NCBI GEO
- PubMed 41173791 pubmed.ncbi.nlm.nih.gov/41173791 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE297452 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |