Omics · study · 2026
Transcriptomic responses to a PDE4DIP-directed siRNA in MDA-MB-231 breast cancer cells
Listed in NCBI GEO
PDE4DIP/myomegalin is a Golgi- and centrosome-associated scaffold encoded by a complex alternatively spliced gene.
Description
This dataset contains RNA-sequencing profiles of MDA-MB-231 breast cancer cells treated with a PDE4DIP-directed siRNA or a negative-control siRNA. The 21-nt siRNA target sequence is present in multiple protein-coding PDE4DIP RefSeq transcripts, including the transcript encoding MMG8/SMYLE, and therefore does not support MMG8-specific attribution.
Three independent experimental pairs were analyzed. Differential-expression and gene set enrichment analyses were used to characterize transcriptional responses associated with siPDE4DIP treatment, including changes in cytoskeletal, membrane-trafficking, small-GTPase, lysosomal, translation, and ribosome-related programs. These data describe transcriptomic responses to a PDE4DIP-directed siRNA in MDA-MB-231 cells and do not establish isoform-specific or causal pathway regulation.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE327nnn/GSE327958 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE327958 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1453393 ncbi.nlm.nih.gov/bioproject/PRJNA1453393 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE327958 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |