Omics · study · 2026
JUP drives a PDGFB-JAK-STAT signaling axis to promote ovarian cancer progression
Listed in NCBI GEO
The Janus kinase (JAK) signaling pathway is frequently associated with ovarian cancer (OC) progression.
Description
However, inhibition of JAK signaling has achieved limited therapeutic effects in OC patients, highlighting the need to elucidate the mechanisms underlying JAK dysregulation in OC development. Here, we demonstrate that Junction plakoglobin (JUP) acts as a positive regulator in the JAK signaling pathway in OC.
Clinically, JUP expression is significantly upregulated and correlates with poor prognosis in OC patients. Phenotypically, depletion of JUP suppresses OC cell proliferation and migration, whereas overexpression of JUP yielded opposite effects. Mechanistically, JUP drives a PDGFB-JAK-STAT signaling axis through interaction with GABPA.
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Collectively, our findings establish an oncogenic role of JUP in OC progression via upregulation of JAK signaling and suggest that JUP represents a potential therapeutic target in JAK-driven OC.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE337nnn/GSE337668 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE337668 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1490569 ncbi.nlm.nih.gov/bioproject/PRJNA1490569 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE337668 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |