Data · dataset · 2026
Opioid dependence vulnerability in a rodent model
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32641062.v1
<p>Opioid use disorder (OUD)remains a global public health crisis, with an estimated 35 million individualsaffected by drug use disorders worldwide.
Description
Opioids account for the highestmortality rates among these substances, prompting several national health emergencies,including the 2017 declaration in the United States following 47,000opioid-related deaths—a 13% increase from the previous year. While the U.S. hasreceived significant attention, regions such as Ireland and Britain,particularly Scotland, have also reported alarmingly high rates of opioidmisuse and mortality.
This thesis investigates the biological mechanismsunderlying opioid addiction through a multi-omic analysis in rodent models,incorporating transcriptomic, epigenomic, and microbiome data.</p><p> </p><p>Gene expression profiling was conducted in brain regions integralto addiction pathways, including the ventral tegmental area, nucleus accumbenscore and shell, and dentate gyrus. Differential expression and gene setanalyses highlighted immune response, metabolism, and signal transduction askey pathways associated with addiction vulnerability.
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Complementary epigeneticanalysis of blood samples collected prior to drug exposure revealed DNAmethylation differences between addiction-vulnerable and resilient animals,with notable alterations in genes linked to neurodevelopment, particularly theWNT signalling pathway. Hypomethylation of Gpr83, a gene associated withanxiety, was specifically observed in vulnerable females, suggesting itspotential as a predictive biomarker.
Further, gut microbiome analysisdemonstrated that heroin exposure significantly alters microbial composition,with distinct signatures emerging before, during, and after drug intake.Microbiome data from a rodents on a diet of hyperpalatable food identifiedlimited overlap in the microbes impacted by opioid and hyperpalatable food.</p><p> These findings contribute to a deeper understanding of thebiological basis of OUD and offer new avenues for biomarker discovery andtherapeutic development.</p><p><i>Thesis is embargoed until 31 July 2030.</i><br></p>
Links
Where it is published
- DOI doi.org/10.17034/32641062.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
Provenance · 3 source records, 14 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32641062 | 12 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32641062 | 12 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32641062 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].anzsrc:field:310504 | mapping · figshare dmu ac uk | vocabulary-mapper@1.0.0 | keywords['epigenetics'] |
| concepts[field].anzsrc:field:310504 | mapping · zivahub uct ac za | vocabulary-mapper@1.0.0 | keywords['epigenetics'] |
| concepts[field].anzsrc:field:310504 | mapping · dro deakin edu au | vocabulary-mapper@1.0.0 | keywords['epigenetics'] |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |