Omics · study · 2026
DSS chronic colitis induces osteoporosis by changing osteal macrophages to an inflammatory phenotype.
Listed in NCBI GEO
Osteal macrophages are bone-resident macrophages.In this study, we investigated the functional properties of Osteal macrophages in osteoporosis caused by chronic colitis.
Description
In this study, we investigated the functional properties of Osteal macrophage in osteoporosis caused by chronic colitis.We found that Osteal macrophages are altered in an inflammatory manner and affect osteoblast and osteoclast differentiation. To understand this mechanism, we isolated and collected Osteal macrophages from mice with DSS-induced colitis and comprehensively analyzed changes in gene expression by bulk RNA analysis
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE295nnn/GSE295136 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE295136 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1253592 ncbi.nlm.nih.gov/bioproject/PRJNA1253592 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE295136 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |