Table · study · 2026
Spatial transcriptomic profiling of ischemia-reperfusion injured mouse kidneys reveals niche-specific metabolic dysfunction
Listed in NCBI GEO
This study presents spatial transcriptomic data from mouse kidneys subjected to ischemia-reperfusion injury to investigate the molecular underpinnings of localized tissue responses.
Description
Using high-resolution Stereo-seq spatial transcriptomics, we profiled gene expression across healthy and injured renal microenvironments, focusing on areas surrounding failed repair proximal tubule (FR-PT) cells. Transcriptomic analysis revealed distinct niches characterized by downregulation of oxidative phosphorylation and fatty acid β-oxidation pathways, even in proximal tubule cells considered heatlhy.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298899 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298899 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1270778 ncbi.nlm.nih.gov/bioproject/PRJNA1270778 ↗
project · from NCBI GEO
Topics
- Stated by source
- Mus musculus · Other
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE298899 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:other | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |