Omics · study · 2026
YAP Induces a Pro-Renewal Metabolic State in Cardiomyocytes: Cardiomyocyte-enriched Datasets
Listed in NCBI GEO
Cardiomyocyte (CM) maturation is characterized by a change in energy metabolism from glucose to fatty acid catabolism, which poses a barrier to CM proliferation and cardiac regenerative repair.
Description
YAP, a transcriptional cofactor that is regulated by the Hippo signaling pathway, induces cardiac regenerative repair. We investigated YAP function in postnatal metabolic maturation and remodeling and found that YAP inhibits fatty acid catabolism and shifts fatty acid catabolism to anabolism with phospholipid biosynthesis.
Moreover, YAP induced metabolic remodeling enhances CM carbohydrate utilization. Functional experiments using maternal dietary fat challenge, which stimulates fatty acid oxidation (FAO) and induces CM maturation, counteracts YAP-induced metabolic remodeling. Mechanistically, we discover that YAP inhibits the MEF2A directed maturation program leading to a neonatal-like CM metabolic state.
Read the rest (1 more)
We provide a transcriptional framework by which YAP induces neonatal CM metabolic remodeling to reverse CM metabolic maturation, thereby promoting heart regeneration.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE291nnn/GSE291780 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE291780 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1235232 ncbi.nlm.nih.gov/bioproject/PRJNA1235232 ↗
project · from NCBI GEO
- PubMed 41797725 pubmed.ncbi.nlm.nih.gov/41797725 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Heart 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE291780 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[anatomy].local:anatomy:heart | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |