Omics · study · 2026
RNA-seq technique to identify key differentially expressed genes in hepatocytes of HFD-treated Lyve1-Cre;Heg1fl/fl mice.
Listed in NCBI GEO
Heart-of-glass (Heg) is a type I transmembrane protein.
Description
Previous studies have demonstrated that knockout of the Heg1 gene in mouse liver endothelial cells disrupts hepatic metabolic zonation by downregulating Wnt ligands in endothelial cells. To further investigate the metabolic changes in hepatocytes, alterations in Wnt receptor genes, and other potential genetic changes following endothelial-specific Heg1 knockout in mice with hepatic steatosis, this study was conducted.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE315nnn/GSE315356 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE315356 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1396585 ncbi.nlm.nih.gov/bioproject/PRJNA1396585 ↗
project · from NCBI GEO
- PubMed 42119921 pubmed.ncbi.nlm.nih.gov/42119921 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE315356 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |