Omics · study · 2026
Growth hormone (GH) suppresses DNA damage repair in human prostate epithelial cells
Listed in NCBI GEO
In normal prostate, DNA damage accumulates with age, resulting in local GH induction.
Description
Age-associated local GH abundance enables further DNA damage accumulation. Employing RNA sequencing, we report here that genes related to DNA damage repair were found to be significantly suppressed in primary human prostate epithelial cells (HPrEC) line 1 and in line 2, in 3 independent experiments after treatment with 100 ng/mL GH for 24 h.
BRCC3, TAF5, H4C16, NUDT16L1, and TADA3 , all pivotal in DNA damage repair were significantly downregulated. The data revealed mechanisms underlying GH-induced unrepaired DNA damage accumulation in prostate epithelial cells.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE298nnn/GSE298387 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE298387 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1269057 ncbi.nlm.nih.gov/bioproject/PRJNA1269057 ↗
project · from NCBI GEO
- PubMed 42518286 pubmed.ncbi.nlm.nih.gov/42518286 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE298387 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |