Excel · study · 2026
Alternative splicing- and gene fusion-derived neoepitopes in MASLD-associated hepatocellular carcinoma
Listed in NCBI GEO
Metabolic dysfunction-associated steatotic liver disease (MASLD)-driven hepatocellular carcinoma (HCC) exhibits reduced responsiveness to immune checkpoint blockade compared with viral or other etiologies, suggesting underlying differences in tumor immunogenicity and immune evasion.
Description
To characterize the immunogenic landscape of MASLD-driven HCC, we profiled transcriptomic data from 120 liver tissue samples, including healthy controls (n = 12), MASLD samples (n = 13), and MASLD-associated HCC samples (n = 95), and investigated the contribution of transcriptome-derived neoantigens to this altered immune landscape, focusing on alternative splicing and gene fusion events as non-canonical sources of tumor-specific epitopes.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE334nnn/GSE334651 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE334651 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1467981 ncbi.nlm.nih.gov/bioproject/PRJNA1467981 ↗
project · from NCBI GEO
- PubMed 41592600 pubmed.ncbi.nlm.nih.gov/41592600 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE334651 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |