Omics · study · 2026
The PARP Inhibitor Talazoparib efficiently Suppresses Tumor Growth in Castration-Resistant Prostate Cancer
Listed in NCBI GEO
To address the limited understanding of PARP inhibitor monotherapy in castration-resistant prostate cancer (CRPC), we investigated the antitumor effects of Talazoparib in CRPC cells with homologous recombination repair (HRR) gene mutations.
Description
We treated DU 145 and PC-3 cells with Talazoparib and observed reduced proliferation, migration, and colony formation. Western blot analysis showed increased apoptosis and DNA damage.
RNA sequencing revealed downregulation of key HRR genes (BRCA1/2, ATM, ATR), and gene set enrichment analysis confirmed suppression of DNA repair pathways and activation of immune-related responses. These findings suggest that Talazoparib not only exploits synthetic lethality but also impairs HRR gene expression, supporting its potential as monotherapy in HRR-deficient CRPC.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE303nnn/GSE303244 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE303244 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1294391 ncbi.nlm.nih.gov/bioproject/PRJNA1294391 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE303244 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |