Dataset for "A predictive score to identify high transmission-risk households of individuals newly diagnosed with pulmonary tuberculosis in rural South Africa"

This secondary data analysis used data collected as part of TB household case-contact study (Africa Health Research Institute (AHRI) Household Contact study) investigating M. tuberculosis (MTB) transmission in rural KwaZulu-Natal, South Africa.

A key focus of the study was to better understand how HIV status, antiretroviral treatment (ART), and symptom presentation affect infectiousness of the index person with TB. The study recruited adults with bacteriologically-confirmed pulmonary TB from routine health services and tested their child household contacts (aged 2-14 years) for evidence of immunoreactivity to MTB using QuantiFERON TB Gold plus assay. By comparing prevalence of MTB immunoreactivity among children exposed to index cases with different HIV/ART statuses and symptom profiles, the research aimed to quantify within-household transmission risk and inform TB screening strategies.