Omics · study · 2026
Immune Context Governs Stage-Specific Responses to Depleting Anti-PD-1 Antibody in Type 1 Diabetes
Listed in NCBI GEO
A depleting anti-PD-1 antibody (D-aPD-1) exhibits striking stage-dependent effects in a mouse model of T1D: delaying hyperglycemia onset in early insulitis (E-insulitis) but paradoxically accelerating disease in late insulitis (L-insulitis).
Description
Compared with E-insulitis, L-insulitis pancreatic islets show elevated immune cell infiltration, a pronounced Teff/Treg imbalance, and enrichment of proinflammatory macrophages—features that partially mirror human T1D pathology.
Comprehensive analyses of the islet immune microenvironment identified macrophages as the primary mediators underlying these divergent therapeutic outcomes. Specifically, D-aPD-1 markedly enhances macrophage accumulation, FcgR expression, and the activation of IFN-a/g and TNF-a response pathways. The antibody further amplifies macrophage production of proinflammatory cytokines and chemokines.
Read the rest (1 more)
Among macrophage subsets, Mac-3 predominantly mediates these responses to D-aPD-1. Collectively, proinflammatory macrophages and their interactions with D-aPD-1 are critically determinants of therapeutic outcome.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE328nnn/GSE328069 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE328069 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1453789 ncbi.nlm.nih.gov/bioproject/PRJNA1453789 ↗
project · from NCBI GEO
- PubMed 42746516 pubmed.ncbi.nlm.nih.gov/42746516 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE328069 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |