Omics · study · 2026
Transcriptomic analysis of cancer-associated thrombosis in plasma EVs from patients with advanced lung adenocarcinoma.
Listed in NCBI GEO
Venous thromboembolism (VTE) is a major contributor to morbidity and mortality in patients with advanced lung adenocarcinoma.
Description
Extracellular vesicles (EVs) are established mediators of the associated hypercoagulable state. We conducted a transcriptomic analysis of plasma EVs to identify molecular signatures specific to cancer-associated thrombosis (CAT) for refined risk stratification and therapeutic targeting.
Methods
Read the rest (2 more)
Plasma EVs from lung adenocarcinoma patients with (n=10) and without (n=11) VTE were analyzed by RNA-Sequencing. Differentially Expressed Genes (DEGs) were analyzed for pathway enrichment. Results: RNA-Seq identified 483 DEGs in VTE patients, with significant enrichment in pathways related to inflammation, neutrophil degranulation (NETs), and blood coagulation.
Conclusion: Plasma EVs carry a potent, multi-cellular derived immuno-thrombotic mRNA signature that distinctly underlies CAT in lung adenocarcinoma.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE313nnn/GSE313339 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE313339 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1378989 ncbi.nlm.nih.gov/bioproject/PRJNA1378989 ↗
project · from NCBI GEO
- PubMed 42353272 pubmed.ncbi.nlm.nih.gov/42353272 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE313339 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |