Developmental Arrest Associated with Altered Cerebellar Metabolism in Sudden Infant Death Syndrome

We performed bulk RNA sequencing of flash-frozen postmortem human cerebellar cortex from SIDS infants and age-matched non-SIDS controls to define transcriptional alterations associated with SIDS. Differential-expression and pathway-enrichment analyses were used to evaluate neuroinflammatory, neurotransmitter, and metabolic programs, and transcriptomic findings were compared at the pathway level with independently generated targeted metabolomics and quantitative histology data.