Omics · study · 2026
RNA-seq of B-cell lymphoma treated with Ibrutinib and CAR T cells
Listed in NCBI GEO
This dataset presents RNA sequencing (RNA-seq) data from human B-cell lymphoma HT tumors established in immunodeficient mice.
Description
Tumors were treated with ibrutinib (IB), CD19-directed chimeric antigen receptor T cells (CAR T cells), or a combination of both. The study aimed to investigate transcriptomic changes and treatment-related gene expression differences induced by monotherapy or combination therapy.
These data provide insight into the molecular responses to IB and CAR T-cell treatment in vivo and may help elucidate mechanisms underlying therapeutic synergy.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE299nnn/GSE299395 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE299395 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1274356 ncbi.nlm.nih.gov/bioproject/PRJNA1274356 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE299395 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |