Data · dataset · 2025
Identification and Prognostic Significance of Ki-67-related Genes in Triple Negative Breast Cancer
Listed in ScienceDB
Description
Objective: This study was aimed to screen and validate key genes associated with Ki-67 expression and evaluate their prognostic significance in patients with triple-negative breast cancer (TNBC).Methods and Results: RNA sequencing data and clinical characteristics were obtained from the Fudan University Shanghai Cancer Center (FUSCC) database. A Cox regression model and bioinformatic analyses were employed to identify Ki-67–related prognostic genes.
Candidate genes were further validated using the Kaplan-Meier Plotter database and patient specimens from our medical center. A total of 241 differentially expressed genes between high and low Ki-67 expression groups were initially identified through Gene Ontology functional analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment. Further analysis revealed that CCNA2, a Ki-67–related gene, was an independent risk factor for overall survival.
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Patients with high-risk scores exhibited significantly higher mortality rates than those with low-risk scores. Moreover, immunohistochemistry analysis showed that high CCNA2 protein expression was significantly associated with histological grade and recurrence or metastasis within 3 years after surgery (all P < 0.05).Conclusions: CCNA2 overexpression may contribute to tumorigenesis and serve as a potential prognostic biomarker indicating poor outcomes in TNBC.
Links
Where it is published
- DOI doi.org/10.57760/sciencedb.27478 ↗
DOI / persistent id · from scidb cn
Catalogue records · 1
- OAI-PMH record scidb.cn/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=10.57760%2… ↗
metadata API · from scidb cn
Topics
- From keywords
- Earth & Environmental Science · Engineering · Humanities · Life Sciences · Medicine & Health · Social Science
- Inferred from text
- Cancer 75% · Oncology and carcinogenesis 73% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 15 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ScienceDB | 10.57760/sciencedb.27478 | 9 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3211 | enrichment · scidb cn | taxonomy-embedding@1.0.0 | title+keywords+description (73%) |
| concepts[field].local:field:earth-environmental | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:engineering | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:humanities | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[field].local:field:social-science | mapping · scidb cn | connector:scidb_cn@1.0.0 | |
| concepts[modality].local:modality:rna-seq | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · scidb cn | keyword-concept-rules@1.0.0 | title+description (75%) |
| description | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/description |
| license | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/rights |
| publication_date | source · scidb cn | connector:scidb_cn@1.0.0 | |
| title | source · scidb cn | connector:scidb_cn@1.0.0 | /metadata/dc/title |