Omics · study · 2026
ChIP-seq analysis of HT-29 cells treated with the KDM5B inhibitors JB-157 or JB-161
Listed in NCBI GEO
KDM5B, a member of the KDM5 family of histone demethylases, functions as a key epigenetic regulator by removing di- and trimethyl groups from H3K4 (H3K4me2/3), thereby promoting transcriptional repression.
Description
It is involved in fundamental biological processes, including development, stem cell maintenance, and tumorigenesis, and its dysregulation has been associated with multiple cancer types. Given its critical role in cancer biology, KDM5B has emerged as an attractive target for therapeutic intervention.
Therefore, we conducted a screening campaign to identify novel KDM5B inhibitors. In this study, we investigated whether the KDM5B inhibitors JB-157 and JB-161, identified through our screening, induce chromatin remodeling in HT-29 cells.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE319nnn/GSE319663 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE319663 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1424928 ncbi.nlm.nih.gov/bioproject/PRJNA1424928 ↗
project · from NCBI GEO
- PubMed 42324589 pubmed.ncbi.nlm.nih.gov/42324589 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Genome binding/occupancy profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE319663 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:genome-binding-occupancy-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |