Omics · study · 2026
Chronic hypobaric hypoxia induces exposure-duration-dependent transcriptomic remodeling in the mouse cochlea
Listed in NCBI GEO
To investigate cochlear transcriptomic responses to chronic hypobaric hypoxia, male C57BL/6J mice were assigned to an ambient-pressure control group or exposed to simulated high-altitude hypobaric hypoxia for 2, 4, or 6 weeks.
Description
A staggered-entry design was used so that all groups underwent terminal cochlear tissue collection on the same day. Bulk RNA sequencing was performed on 20 independent cochlear samples, with five biological replicates per group.
The study identified exposure-duration-associated transcriptional changes involving mitochondrial and intermediary metabolism, lipid metabolism, vascular/barrier-related signatures, and immune-related transcriptional features.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE343nnn/GSE343744 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343744 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1512482 ncbi.nlm.nih.gov/bioproject/PRJNA1512482 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE343744 | 9 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |