Excel · study · 2026
Effects of norepinephrine(NE) and dexamethasone(DEX) exposure on signaling pathways in immortalized primary human trabecular meshwork cells.
Listed in NCBI GEO
Aqueous humor drainage through the trabecular meshwork is regulated in part by hormonal cues, including norepinephrine (NE) and dexamethasone (DEX), and its circadian variation is thought to reflect rhythmic changes in these signals.
Description
However, the transcriptional programs and molecular pathways through which NE and DEX influence human trabecular meshwork cells remain incompletely defined. In this study, we performed RNA-seq analysis of immortalized human primary trabecular meshwork cells (abm; T0371) exposed to NE or DEX for 6 hours, with vehicle-treated cells as controls, to identify stimulus-responsive genes and pathways associated with trabecular meshwork function and aqueous humor outflow.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE336nnn/GSE336386 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE336386 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1481510 ncbi.nlm.nih.gov/bioproject/PRJNA1481510 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE336386 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |