Omics · study · 2026
Transcriptomic analysis of perfluorobutane Sulfonic Acid (PFBS) in two human placental models
Listed in NCBI GEO
Perfluorobutane sulfonic acid (PFBS) is a short-chain replacement per- and polyfluoroalkyl substance (PFAS) increasingly detected in drinking water and human serum.
Description
Prenatal PFBS exposure has been epidemiologically associated with hypertensive disorders of pregnancy, including preeclampsia, and increased offspring adiposity; however, the toxicological mechanisms underlying these associations and the effects of PFBS on human placental tissue remain poorly characterized.
With a transplacental transfer efficiency of approximately 97%, PFBS undergoes near-complete transfer to the fetal compartment, underscoring the placenta as a critical target for PFBS toxicity. This study investigated the transcriptional and functional effects of PFBS in human trophoblast cells and term placental villous explants, stratified by fetal sex, to characterize mechanisms of PFBS bioactivity relevant to placental function.
Read the rest (1 more)
Term chorionic villous explants (obtained from with informed consent from elective non-laboring c-sections) from male and female placentas were exposed to 5 or 20 µM PFBS and analyzed by RNA-seq with sex-stratified differential gene expression and gene set enrichment analysis (GSEA) using the MSigDB Hallmark gene set collection.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE342nnn/GSE342484 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE342484 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1507965 ncbi.nlm.nih.gov/bioproject/PRJNA1507965 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE342484 | 15 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |