Omics · study · 2026
Transcriptomic profiling of gastrocnemius muscle from young, aged, and UA-30-treated aged mice
Listed in NCBI GEO
Skeletal muscle aging is accompanied by functional decline, fibrosis, and mitochondrial dysfunction.
Description
To characterize transcriptional changes associated with natural aging and UA-30 treatment, RNA sequencing was performed on gastrocnemius muscle from young mice, saline-treated aged mice, and aged mice treated orally with UA-30 (100 mg/kg once daily for 10 weeks). Four independent biological replicates were analyzed per group.
This dataset was used to identify age-associated genes whose expression was oppositely regulated by UA-30 and to examine enriched biological processes.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE341nnn/GSE341601 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE341601 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1503003 ncbi.nlm.nih.gov/bioproject/PRJNA1503003 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE341601 | 14 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |