Omics · study · 2026
RNA N6-Methyladenosine (m6A) regulates cell cycle progression in Diffuse Midline Glioma (DMG) and confers sensitivity to FTO inhibition
Listed in NCBI GEO
The epitranscriptome has not previously been evaluated in DMG.
Description
Given the pivotal role of m6A in normal OPC biology, investigating its dysregulation in DMG could uncover new therapeutic options and improve our understanding of the disease's underlying mechanisms. Here, for the first time, we perform direct RNA-sequencing on patient-derived DMG cultures to generate transcript and base-resolution m6A landscapes of DMG.
Furthermore, we interrogate the therapeutic benefits of the Fat mass and obesity associated (FTO) player inhibitor FB23-2 in DMG using direct RNA sequencing and RNA sequencing
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE279nnn/GSE279022 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE279022 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJEB80588 ncbi.nlm.nih.gov/bioproject/PRJEB80588 ↗
project · from NCBI GEO
- PubMed 41888518 pubmed.ncbi.nlm.nih.gov/41888518 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE279022 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |