Omics · study · 2026
KRT6A enhances radiotherapy resistance in lung squamous cell carcinoma via activation of the autophagy pathway through RAB39B [RNA-Seq 1]
Listed in NCBI GEO
Description
Background
Radiotherapy is the cornerstone for lung squamous cell carcinoma (LUSC) treatment, yet its efficacy is often limited by the development of radioresistance. Understanding the molecular mechanisms driving this resistance is critical for improving therapeutic outcomes. Results: In this study, we established a radioresistant LUSC cell line and identified KRT6A as a pivotal gene involved in radiotherapy resistance.
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Transcriptome sequencing and further validation revealed RAB39B as a downstream target of KRT6A. The KRT6A-RAB39B axis promotes radioresistance by activating the autophagy pathway, enhancing cancer cell survival in response to radiation stress. Mechanistic studies confirmed that KRT6A regulates autophagy through modulation of RAB39B expression.
Conclusions：This work is the first to uncover a role of the KRT6A-RAB39B axis in LUSC radioresistance, offering new insights into the mechanisms and potential targets underlying radiotherapy failure.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE301nnn/GSE301225 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE301225 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1284301 ncbi.nlm.nih.gov/bioproject/PRJNA1284301 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75% · RNA sequencing 65% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE301225 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |