Omics · study · 2026
Transcriptomic profiling of CT26 tumor-bearing mice treated with novel HDAC inhibitor GNTbm-38
Listed in NCBI GEO
Histone deacetylase inhibitors (HDACis) represent a promising therapeutic strategy in cancer treatment.
Description
In this study, we evaluated the therapeutic efficacy and molecular mechanisms of GNTbm-38, a novel HDAC inhibitor, using a syngeneic CT26 colon carcinoma tumor-bearing mouse model. BALB/c mice bearing subcutaneous CT26 tumors were treated with vehicle control or GNTbm-38.
Bulk RNA-sequencing was performed on tumor tissues to characterize transcriptomic alterations induced by GNTbm-38. This dataset provides comprehensive gene expression profiles to elucidate the antitumor and immunomodulatory pathways regulated by GNTbm-38 in colorectal cancer.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE347nnn/GSE347712 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE347712 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1531040 ncbi.nlm.nih.gov/bioproject/PRJNA1531040 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Cancer 75%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE347712 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |