Omics · study · 2026
Loss of YY1 in Purkinje Cells Triggers Cerebellar Ataxia via Wnt10b-Mediated Impairment of Dendrite Development
Listed in NCBI GEO
The cerebellum relies on Purkinje cells (PCs) to coordinate motor functions and maintain neural circuitry.
Description
Impaired PC dendritogenesis is linked to neurological disorders, yet intrinsic molecular mechanisms remain unclear. We demonstrate that postnatal deletion of Yin Yang 1 (Yy1) in PCs disrupts dendrite and spine formation, impairs synaptic plasticity, and alters Protein kinase C gamma (PKCγ) expression, leading to cerebellar ataxia and progressive atrophy.
Mechanistically, YY1 transcriptionally activates wingless-type MMTV integration site family, member 10B (Wnt10b), which signals through Frizzled-4 (Fzd4) in PCs. Wnt10b downregulation mimics the dendritic defects seen in Yy1 mutants, indicating its crucial role in dendrite growth and synaptic environment regulation. These changes result in defective synapse innervation.
Read the rest (1 more)
Our findings reveal that YY1 governs PC dendritogenesis and synaptogenesis via Wnt10b, while also modulating PKCγ and β-catenin signaling. The YY1-Wnt10b axis emerges as a critical pathway underlying YY1-associated cerebellar dysfunction.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE336nnn/GSE336211 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE336211 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1481079 ncbi.nlm.nih.gov/bioproject/PRJNA1481079 ↗
project · from NCBI GEO
- PubMed 42572605 pubmed.ncbi.nlm.nih.gov/42572605 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE336211 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |