Omics · study · 2026
NAT10-mediated N4-acetylcytidine modification drives RNA splicing of PML to alleviate adipose-derived stem cell senescence and promote diabetic wound healing
Listed in NCBI GEO
Cellular senescence in adipose-derived stem cells (ADSCs) limits their application in diabetic wounds.
Description
Alternative splicing generates multiple isoforms that play critical roles in modulating stem cell senescence. N-acetyltransferase 10 (NAT10) regulates N4-acetylcytidine (ac4C) modification, which has been implicated in RNA splicing.
As the role of NAT10 in ADSCs remains elusive, this study aimed to investigate the function of NAT10 in ADSC senescence and RNA splicing.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE326nnn/GSE326590 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE326590 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1445971 ncbi.nlm.nih.gov/bioproject/PRJNA1445971 ↗
project · from NCBI GEO
- PubMed 42281170 pubmed.ncbi.nlm.nih.gov/42281170 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE326590 | 12 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |