Excel · study · 2026
Transcriptomic profiling of osteosarcoma patients with good and poor response to MAP regimen
Listed in NCBI GEO
Purpose: The overall objective of this study is to identify the differentially expressed genes and transcriptomic features associated with chemotherapy response in osteosarcoma patients treated with the MAP regimen (Methotrexate, Doxorubicin, and Cisplatin).
Description
Methods
High-throughput transcriptome sequencing (RNA-seq) was performed on 9 osteosarcoma patient tumor tissue samples. Based on histological assessment, samples were categorized into 4 'good responders' (≥90 tumor necrosis) and 5 'poor responders' (≤60 tumor necrosis) to evaluate transcriptomic profiles corresponding to therapeutic responsiveness.Results: Using an optimized bioinformatics analysis pipeline, we identified key differentially expressed genes (DEGs) and enriched signaling pathways distinguishing good from poor responders.
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These findings provide valuable insights into the transcriptomic landscape of chemoresistance and potential biomarkers for osteosarcoma therapeutic strategy.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE342nnn/GSE342958 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE342958 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1509516 ncbi.nlm.nih.gov/bioproject/PRJNA1509516 ↗
project · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Homo sapiens
- From keywords
- Life Sciences
- Inferred from text
- Cancer 65% · RNA sequencing 65% · Sequencing 75%
Provenance · 1 source records, 10 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE342958 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |