Omics · study · 2026
DNA methylation profiling of NK cells and Classical Monocytes from maternally HIV exposed and unexposed children
Listed in NCBI GEO
Differences in morbidity, immune responses, growth and developmental outcomes have been described in children exposed to HIV but uninfected (CHEU), compared with children unexposed to HIV (CHU).
Description
In order to determine if there is a maternal imprinting on the immune system in children we profiled the DNA methylation landscape by reduced representation bisulfite sequencing (RRBS) in CD56dim NK cells and CD14+ classical monocytes isolated from the PBMC of children that were exposed in utero to HIV but ininfected (HEU) versus children non-infected with HIV and not exposed (HUU).
The HEU group was additionaly stratified by those children who were maternally infected before or during pregnacy. These data begin to define the longtidinal effects of maternal HIV exposure on the innate immune system over the first year of life.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE343nnn/GSE343621 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE343621 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1511990 ncbi.nlm.nih.gov/bioproject/PRJNA1511990 ↗
project · from NCBI GEO
Topics
- Stated by source
- Homo sapiens · Methylation profiling by high throughput sequencing
- From keywords
- Life Sciences
- Inferred from text
- DNA methylation profiling 75% · Sequencing 75%
Provenance · 1 source records, 9 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE343621 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:methylation-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[method].local:method:dna-methylation-profiling | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:9606 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |