PROtection MEdiated by Antioxidant NanoTEchnOlogy Against Neuronal Damage in Space 2 (PROMETEO 2, Nano Protection)

This project proposes the use of cerium oxide nanoparticles (nanoceria or NC, in space and on ground) and polydopamine-based nanoparticles (NP, on ground) to provide 1) antioxidant protection and 2) catecholaminergic support to neurons undergoing exposure to altered gravity and radiation. The focus is on neuronal cells involved in cognitive and motor functions both in space, where any behavioural impairments pose significant risks to manned expeditions, and on Earth, where dopaminergic neuron loss underlying Parkinson’s disease (PD) progression still requires effective contrast.

This project in particular aims at exploring the connection between spaceflight and OS, by discriminating the effects of MG from those of CR, and at providing nanotechnology countermeasures to short- and potentially long-term alterations of the CNS due to spaceflight-induced reduction/oxidation (redox) reaction imbalance. This project also aspires at providing relevant evidence and therapeutic tools for the treatment of neurodegenerative conditions like PD on Earth.