Omics · study · 2026
Peripheral double-negative T cells are enriched in the ovary and uterus and decline in mouse models of autoimmunity and IFN-γ-driven inflammation
Listed in NCBI GEO
Conventional NK1.1⁻ αβ DNTs are enriched in the mouse ovary and uterus and show a regulatory-like, CD8-distinct transcriptional program (low Cd8a/Cd8b1, Il7r, and cytotoxic genes; high Pdcd1, Lag3, Tox, Il10).
Description
Ex vivo, splenic DNTs have low effector output and suppress CD8⁺ T-cell proliferation mainly via contact-dependent mechanisms. In vivo, reproductive-tissue DNTs show tissue-restricted behavior, decline in IFN-γ-driven and ZP3-induced ovarian inflammation, and the DNT:CD8⁺ T-cell balance shifts toward activated CD8⁺ T cells.
Adoptive transfer of WT DNTs improves pregnancy frequency in IFN-γ-mediated infertility.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE317nnn/GSE317190 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE317190 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1406247 ncbi.nlm.nih.gov/bioproject/PRJNA1406247 ↗
project · from NCBI GEO
- PubMed 42324294 pubmed.ncbi.nlm.nih.gov/42324294 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
Provenance · 1 source records, 7 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE317190 | 11 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |