Data · dataset · 2026
Enhancing the neoadjuvant treatment of rectal cancer by targeting the Inhibitor of Apoptosis Proteins
Listed in ZivaHub and Deakin Research Online and DMU Figshare — shown once because both records carry DOI 10.17034/32805587.v1
Total neoadjuvant therapy (TNT) has emerged as a standard approach for locally advanced rectal cancer, combining (chemo)radiation and systemic chemotherapy prior to surgery.
Description
This strategy improves tumour downstaging, increasing the likelihood of non-operative management, and reduces local and distant recurrence. However, most patients still require major surgery, and approximately 25% ultimately relapse.
Enhancing tumour cell death during TNT may improve these outcomes.<br><br>Inhibitor of Apoptosis Proteins (IAPs) are upregulated in rectal cancer and are associated with treatment resistance and poor prognosis. Additionally, intratumoral bacteria such as Fusobacterium nucleatum may contribute to IAP-mediated resistance. This thesis investigates whether pharmacological inhibition of IAPs using the Smac-mimetic tolinapant can enhance responses to TNT.<br><br><i>Thesis is embargoed until 31 July 2027.</i>
Links
Where it is published
- DOI doi.org/10.17034/32805587.v1 ↗
DOI / persistent id · from zivahub uct ac za
Catalogue records · 1
- OAI-PMH record api.figshare.com/v2/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Af… ↗
metadata API · from zivahub uct ac za
Topics
- From keywords
- Earth & Environmental Science · Earth & Environmental Science · Earth & Environmental Science · Medicine & Health · Medicine & Health · Medicine & Health
- Inferred from text
- Cancer 75% · Oncology and carcinogenesis 70%
Provenance · 3 source records, 13 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| ZivaHub | oai:figshare.com:article/32805587 | 13 d ago | JSON v1 |
| Deakin Research Online | oai:figshare.com:article/32805587 | 13 d ago | JSON v1 |
| DMU Figshare | oai:figshare.com:article/32805587 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[disease].local:disease:cancer | enrichment · zivahub uct ac za | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].anzsrc:group:3211 | enrichment · zivahub uct ac za | taxonomy-embedding@1.1.0 | title+keywords+description (70%) |
| concepts[field].local:field:earth-environmental | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| concepts[field].local:field:earth-environmental | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · dro deakin edu au | connector:dro_deakin_edu_au@1.0.0 | |
| concepts[field].local:field:medicine-health | mapping · figshare dmu ac uk | connector:figshare_dmu_ac_uk@1.0.0 | |
| description | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/description |
| license_text | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| publication_date | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | |
| title | source · zivahub uct ac za | connector:zivahub_uct_ac_za@1.0.0 | /metadata/dc/title |