Omics · study · 2026
Neurotoxicity, α-Synuclein Pathology, and Mitochondrial Dysfunction: A Comparative Study of Three Parkinson’s Disease Mouse Models
Listed in NCBI GEO
The pathogenesis of Parkinson’s disease (PD) is complex, and it is difficult for a single animal model to fully mimic its pathological features.
Description
In this study, a comprehensive analysis of behaviors, PD-like pathologies, and gene and protein expression profiles was carried out in PD mouse models (MPTP-induced, α-Syn A53T transgenic, and MitoPark models). The three PD models showed motor impairments, with MitoPark mice displaying particularly pronounced age-related worsening.
Pathologically, they all exhibited nigrostriatal pathway damage but showed differential patterns of glial cell activation. All three PD model mice showed no α-Syn aggregates. However, a few pS129-α-Syn-positive signals were detected in the substantia nigra of α-Syn A53T transgenic mice.
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Molecularly, RNA sequencing and proteomics revealed significant changes in gene and protein expression, with both unique and common features. Five common differentially expressed genes (Ifi27l2a, Ifitm3, Oasl2, Rtp4, and Ankk1) and two common differentially expressed proteins (Timm8a1 and Sephs1) were identified. Functional enrichment analysis indicated that immune responses, cytokines, and neurotransmitter transport were crucial in PD pathogenesis.
Pathway analysis revealed the involvement of ferroptosis in all models, with additional IL-17 pathway activation specifically in MitoPark mice. These findings provide a comprehensive molecular and phenotypic characterization of PD models, offering valuable insights into disease mechanisms and potential therapeutic targets.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE300nnn/GSE300519 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE300519 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1281101 ncbi.nlm.nih.gov/bioproject/PRJNA1281101 ↗
project · from NCBI GEO
- PubMed 41017689 pubmed.ncbi.nlm.nih.gov/41017689 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- Disease 75% · Mass spectrometry 65% · RNA sequencing 75% · Sequencing 75%
Provenance · 1 source records, 11 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE300519 | 13 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[disease].local:disease:disease | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:mass-spectrometry | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[modality].local:modality:sequencing | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (75%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |