Omics · study · 2026
Transcriptomic profiling of brain tissues from HIV-1 gp120 transgenic mice reveals insights into neuropathogenesis
Listed in NCBI GEO
Despite tremendous progress with antiretroviral therapy, HIV-associated neurocognitive disorders (HAND) remain prevalent, underscoring the need for effective treatments.
Description
Sustained immune activation induced by the HIV-1 glycoprotein gp120 is a proposed mechanism leading to neuronal damage in the central nervous system (CNS). To investigate the gp120-mediated transcriptional changes underlying neuropathogenesis, we performed RNA-sequencing (RNA-seq) analysis on brain tissue samples from HIV-1 gp120 transgenic mice and wild-type (WT) control mice to identify differentially expressed genes (DEGs) in the gp120-expressing brains compared to controls.
Links
Get the data
- GEO FTP directory ftp.ncbi.nlm.nih.gov/geo/series/GSE308nnn/GSE308110 ↗
download · from NCBI GEO
Where it is published
- GEO accession page ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE308110 ↗
landing page · from NCBI GEO
Documentation and papers
- PRJNA1328745 ncbi.nlm.nih.gov/bioproject/PRJNA1328745 ↗
project · from NCBI GEO
- PubMed 41651130 pubmed.ncbi.nlm.nih.gov/41651130 ↗
publication · from NCBI GEO
Topics
- Stated by source
- Expression profiling by high throughput sequencing · Mus musculus
- From keywords
- Life Sciences
- Inferred from text
- RNA sequencing 65%
Provenance · 1 source records, 8 field assertions
| Source | Key | Last seen | Raw |
|---|---|---|---|
| NCBI GEO | GSE308110 | 10 d ago | JSON v1 |
| Field | Assertion | Extractor | Evidence |
|---|---|---|---|
| access_level | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[field].local:field:life-sciences | mapping · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| concepts[method].geo_series_type:expression-profiling-by-high-throughput-sequencing | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /gdstype |
| concepts[modality].local:modality:rna-seq | enrichment · NCBI GEO | keyword-concept-rules@1.0.0 | title+description (65%) |
| concepts[organism].NCBITaxon:10090 | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /taxon |
| description | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /summary |
| publication_date | source · NCBI GEO | connector:ncbi_geo@1.0.0 | |
| title | source · NCBI GEO | connector:ncbi_geo@1.0.0 | /title |